The MRN (MRE11-RAD50-NBS1) complex has been implicated in many aspects of the DNA damage response.
N6-Methyladenosine (m6A) is a widespread, reversible chemical modification of RNA molecules, implicated in many aspects of RNA metabolism.
The viral non-receptor tyrosine kinase v-Src and its cellular homologue c-Src are the most investigated proto-oncogenes, implicated in many aspects of tumour development, including proliferation, survival, adhesion, migration, invasion and metastasis3.
More recently the complex has also been implicated in many aspects of the life cycle of proteins, from quality control during synthesis of peptides, to assembly of protein complexes and protein degradation.
LncRNAs have been implicated in many aspects of epigenetic, transcriptional and translational regulation [104].
The NF-κB pathway has been implicated in many aspects of macrophage activation and function.
Accordingly miRNAs have been implicated in many aspects of central nervous system development and function.
Eps8 has been implicated in many aspects of growth factor signaling and regulation of the actin cytoskeleton [15].
Signaling through MEK→ERK1/2 and PI3 kinases is implicated in many aspects of cell physiology, including the survival of oxidant exposure.
Kinases have been implicated in many aspects of tumorigenesis and several have now been validated as targets for drug therapy [14].
Consequently, it is not surprising that Cullins have been implicated in many aspects of cellular biology, ranging from cell cycle progression, modulation of intra- and intercellular pathways, chromatin remodelling and many more.
