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Subsequent investigations with overexpressed and endogenous Hh pathway components showed that many are localized to the primary cilium (reviewed in [ 2]), and that Hh binding to Ptc appears to remove the Hh-Ptc complex from the cilium, permitting accumulation of Smo, Kif7, Gli2, and Gli3 along the ciliary axoneme or at the tip.
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For example, many of the enzymes that modify histones lack specificity for individual sites and in many cases are localized to their substrates through interactions of adaptor domains.
For sparse networks when, the messaging overhead is low since not that many nodes are localized to be broadcasted in the first place.
Many trends are localized either taxonomically or in time, and there is no evidence to support popular conceptions of evolution as an inexorable march in any direction, be it toward larger size, greater complexity, heightened intelligence, or any other trait.
Among the genes identified in this study are many that are localized to chromosomal regions previously associated with AE and thus are new potential AE candidate genes.
Many golgins are localized to the cis-Golgi and we have previously demonstrated that Scyl1 co-localizes with GM130 and 58K, two cis-Golgi localized proteins [16].
It has been shown that many deacetylases are localized to the cytoplasm or frequently shuttle between the cytoplasm and nucleus.
Number of broadcasts in this phase depends on how many new anchors are localized at each iteration.
Since the targets of many therapeutic agents are localized in subcellular compartments, modulation of nanoparticle cell interactions for efficient cellular uptake through the plasma membrane and the development of nanomedicines for precise delivery to subcellular compartments remain formidable challenges.
Many TRP channels are localized to sensory neurones and play a major role in temperature and mechanical transduction.
A significant percentage of skeletal and cardiac myopathies are linked to genetic mutations in genes encoding sarcomeric, metabolic, and enzymatic proteins [ 173– 176], many of which are localized to the M-region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com