Sentence examples for many apoptotic pathways from inspiring English sources

Caspase-3 is a cysteine protease located in both the cytoplasm and mitochondrial intermembrane space that is a central effector of many apoptotic pathways.

With few exceptions, mitochondria represent an essential component of many apoptotic pathways.

Death-associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine protein kinase involved in many apoptotic pathways [ 26, 27].

Strategies that prolong the life of gctBid may also be worth exploring as degradation of tBid is a control element in many apoptotic pathways and stabilisation of tBid, or proteosome inhibition can greatly amplify apoptosis.

Although many apoptotic pathways modulated by Akt have been described, relatively little is known about the actual molecular mechanisms by which Akt suppresses apoptosis after chemotherapeutic treatment of cancer cells.

Bax is a pro-apoptotic member of the Bcl-2 family that is essential in many apoptotic pathways [ 59, 60] as well as directly interacts with the component forming the mitochondrial permeability transition pore (MPTP) that allows proteins to escape from the mitochondria into the cytosol to initiate apoptosis [ 61– 63].

Membrane lipid rafts are another important element in the initiation of many apoptotic signaling pathways, having a main role in the interaction between bacterial pathogens and hosts.

Many parallels exist between animal and plant apoptotic pathways, and many other components of the animal pathways have been strongly conserved in plants [ 14].

Whilst the KEGG pathway was helpful in visualising the apoptotic pathways, many of the genes on the University of Michigan list of apoptosis regulators [ 15] had to be added onto the pathway.

In accord with the key role of mitochondria in the regulation of many (if not all) apoptotic pathways [ 61- 65], mitochondrial functions and integrity are controlled by a variety of distinct mechanisms.

This form of cell death is particularly appealing for chemotherapeutic agents since many tumor cells have dysfunctional apoptotic pathways and, therefore, apoptosis-inducing agents are not always effective for treating cancer [ 53].