Although many alternative coexpression network methods have been proposed [ 99], WGCNA offers several valuable opportunities including interpretation of module robustness, calculation of network properties, and the possibility of association of modules with external clinical traits.
This Bayesian network, with no other features like genotype, yields an AUC of 0.716±0.001, it outperforms a Naive Bayes network trained with six leaves count for history and current drugs (AUC of 0.698±0.002) and many other alternative networks.
Many alternative co-expression network methods have been proposed in the literature [ 27, 29, 30].
Is related to the concept of hub in a network and the capacity of traversing the network through many alternative paths connecting nodes situated in different extremes.
For metabolic networks, the reason behind the lack of absolute constraints are easily explained: Matter can flow along many alternative routes through a metabolic network.
Moreover, these pathways are not isolated but constitute an interconnected network module containing many alternative routes from inputs to outputs.
Rooted in the context of the emergence of many alternative forms of agriculture and food networks, SFSCs are characterized by the proximity of producers and consumers, either relational – i.e. with few (or even no) intermediaries between producers and consumers – or physical – i.e. a short geographical distance between them (Aubry and Kebir, 2013).
Depending on the topology of the maximal deterministic network there can be many alternative sequences of node separators between the source and target nodes.
Rebuilding the routes after link failures is difficult because not many alternative routes are available in small-scale networks.
For example, information spreading happens quite differently on a grid (like the street network of Manhattan, where there are many alternative routes between two points), a tree (where points are connected by the repeated splitting of branches), or a "small world" network (where there are generally many shortcuts so that any point can be reached from any other in relatively few jumps).
