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However, many additional proteins were also pulled down in the assay (Supplementary Fig. 7A and Supplementary Data 5).
Through associations with many additional proteins, PML-NBs control several cellular functions including p53 activation, apoptosis, senescence, DNA damage repair and innate antiviral responses [4].
They include 159 hypothetical proteins as well as many additional proteins known to be secreted by a T2SS.
The regulation of Bax is a complex process that requires many additional proteins including the pro-apoptotic Bak.
Many additional proteins are also essential, including PAR6, atypic Ca2+- and diacylglycerol-independent protein kinase C (aPKC), and PAR3.
Such therapies may confer important advantages over existing anti-EGFR strategies, since ADAM-mediated ectodomain shedding regulates many additional proteins linked to signal transduction and neoplastic cell behaviour.
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Together with proteins invariantly occurring at the telomeres and providing a telomere "capping" function, many additional protein complexes are regularly found in eukaryotic telomeres.
The complexity of the multicomponent phenol monooxygenase is still far from being understood, since many additional protein components have been recently discovered.
This included known imprinted genes such as ATP10A and SNRPN along with many additional protein-coding genes, pseudogenes and non-coding RNAs that have not been previously reported as imprinted (Additional file 10: Table S6).
Many additional protein interactions are known from various small-scale experiments, such as co-immunoprecipitations or affinity capture, which provide us with data for species in which large-scale studies are not yet available.
Many additional vertebrate proteins are known to bind heparin/heparan sulfate [46], and we are continuing to investigate whether such proteins may also be ligands for leptospiral Len proteins.
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