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Since the advent of the yeast two-hybrid assay, many additional genetic systems based upon the principle of protein fragment complementation have been designed.
For instance, rare familial AD (FAD) forms have an early onset and many additional genetic and environmental risk factors influence the more common sporadic AD (SAD) pathology [ 13].
While the role of neurotransmitters and a few other molecules in mediating and modulating levels of aggression is well established, it is likely that many additional genetic pathways remain undiscovered.
Since the contribution of most of the known risk alleles to the development of type 2 diabetes is rather small, one might conclude that many additional genetic factors are still unknown.
Given that few studies have explicitly assessed genome-wide genetic effects on splicing and alternate isoforms in human tissues there likely remain many additional genetic effects on expression to be discovered.
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We observe that the GCI area under the curve with currently known variants is much less than that of the optimal theoretical genetic models, which suggests that many additional unknown genetic variants and/or interactions are expected to affect these diseases.
Many additional cases of genetic disease have since been traced to LINE-1 retrotransposition mediated gene disruptions in the germ-line.
The combination of anchor loci assigned using AMALs and mapped in the interspecific cross has provided many additional landmarks for aligning genetic linkage maps in A. cepa and A. fistulosum.
The emergence of transmissible drug-resistant Mycobacterium tuberculosis is the result of a multitude of additional genetic mutations, many of which interact, a phenomenon known as epistasis.
Now imagine additional genetic differences cause many genes to change in expression by, say 1.5-fold up or down, a result that has frequently been observed in comparisons between natural isolates.
In many genera, genome reduction, rather than acquisition of additional genetic material, can be associated with increased virulence, as many of the most virulent bacterial pathogens have smaller genomes than closely related species [ 88].
Related(16)
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