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Clearly, many additional experiments need to be carried out to clarify the detailed structure, the exact properties, and the specific potential of these systems.
We feel that as a result of our many additional experiments, we can now propose a novel – and reasonable – hypothesis for the function of the perichromosomal compartment.
In the case of Figures 2 and 6, we had conducted many additional experiments that convinced us the conclusions were quite reproducible, and the experiments themselves have internal controls for reproducibility in terms of closely spaced titrations.
To study the control of food intake, many additional experiments were performed, aiming at the relative contribution of fore- and hindbrain areas, with specific administration of a wide variety of substances into either the 3rd or the 4th ventricle, combined with or without occlusion of the cerebral aqueduct.
Similar(56)
By conducting many additional simulation experiments, we find that this is mainly due to the randomness of network topology generation.
Hence, although our data suggests the 6 subgroup classification of ER + breast cancer may be useful for guiding therapy in patients, many additional validation experiments are required to confirm our findings.
Because a 30 40 nM plasma concentration of digitoxin can be maintained in patients for many days, additional experiments with extended incubation time (6 days) was performed.
Many additional assignments were obtained from this experiment and other 3D experiments on multiple samples, and these assignments and experiments will be discussed in detail in a forthcoming publication.
Peripheral blood mononuclear cells are preferred targets for many retroviruses including MLV and additional experiments are needed to determine the precise replication kinetics of XMRV in human PBMC cultures and the subpopulation of blood cells involved.
While an initial draft sequence for an organism could be determined in a matter of weeks, the complete sequence required many months or even years of additional experiments - a time- and cost-intensive process called genome finishing.
As an author and an editor I sometimes wonder whether these often unnecessary additional experiments, which can take many months, are worth the effort.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com