Sentence examples for many abnormalities including from inspiring English sources

Under certain circumstances, aberrant regulation of this pathway can contribute to abnormal cellular proliferation which may lead to many abnormalities including; autocrine transformation, drug resistance, senescence or premature aging [ 2, 4, 5, 19].

These glands exhibited many abnormalities, including enlarged ducts, alveolar-like development, and preneoplastic lesions.

Mice constitutively deficient for BIM show many abnormalities, including increased white blood cell (WBC) counts, splenomegaly and defects in thymic T-cell selection.

HNSCCs also exhibit many chromosomal abnormalities, including amplifications of the 11q13 region containing the cyclin D1 gene and the 7p11 region encoding EGFR, which lead to proto-oncogene activation.

Many lung abnormalities including emphysema, dysmorphic and highly activated AMs (Lyerla et al. 2003), and higher levels of TGF β1 (this study), appeared much earlier than the overt fibrosis in the HPS double mutant animals.

It has been reported that exposure to VPA during pregnancy causes many developmental abnormalities, including neural tube defects (mostly spina bifida), cardiac, skeletal, and limb defects, and fetal valproate syndrome.

Patients with chronic renal disease and on haemodialysis may develop many different musculoskeletal abnormalities, including secondary hyperparathyroidism, osteomalacia, osteosclerosis, osteoporosis, amyloidosis and a variety of crystal deposition diseases [23].

To our surprise, we noticed an increased proportion of mitotic cells in the Mia1p-MutNES4 strasn, as well as many instances of mitotic spindle abnormalities including monopolar and broken spindles (Fig. 3A and B).

Many chemicals that cause developmental abnormalities, including cardiovascular, neural, and connective tissue defects, are substrates for CYPs, and the oxidative biotransformation of such xenobiotics may determine the cellular and organ targets of those chemicals [ 12].

Many patients with CHF and hyperglycemic symptoms have accompanying abnormalities including obesity, dyslipidemia, and hypertension, which also lead to structural and functional abnormalities of the heart in cardiac dysfunction and CHF [ 3- 6].

Hematologic abnormalities, including anemia, have been reported as prognostic factors in many solid tumors [ 35- 38].