Sentence examples for many Rab effectors from inspiring English sources

We have shown previously that hypervariable domains are important for the binding of many Rab effectors (Aivazian et al., 2006; Burguete et al., 2008).

The G domain is docked onto the dynein heavy chain, while the C-terminal domain binds many of the LIC's protein partners, specifically Rab effectors involved in membrane transport.

Many tethering proteins are known to be either Rab effectors or Rab exchange factors; examples include EEA1 (Christoforidis et al. 1999) and TRAPPI (Cai et al. 2005; Sacher et al. 2001) in endosomal membrane fusion and, more relevant here, TRAPPI (Sacher et al. 2001).

To investigate the mechanism of Rab localization, chimeras containing heterologous Rab hypervariable domains were generated, and their ability to bind seven Rab effectors was quantified.

Previous studies on many Rab proteins in Arabidopsis have been reported in detail.

Examples are Rab-GTPases, which regulate the membrane recruitment and activity of tethering factors; Rab effectors such as phosphatidylinositol kinases; ATP-driven chaperones from the Sec1/Munc18 family, also called SM proteins; and soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) (Alpadi et al. 2012; Guo and McCubbin 2012; Karnik et al. 2013; Ohya et al. 2009).

The LIC C-terminus alone binds Rab effectors.

We sought to identify insulin-activated Rab proteins and Rab effectors that facilitate GLUT4 translocation.

Through association with specific Rab effectors, Rab-GTP facilitates docking of vesicles onto the ERGIC 30.

These include Rab-GTPases [ 1] operating in conjunction with polyphosphoinositides [ 2] and Rab effectors [ 3] that frequently include multiprotein complexes.

Our study is therefore consistent with previous reports that Rab effectors exhibit broad specificity for Rab proteins and interact with multiple Rab isoforms (34).