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This analysis and editing of the manuscript were supported by funding from Abbott Laboratories, Abbott Park, IL, USA.

Unpublished observations cited in this manuscript were supported by funding from the National Institutes of Health (R01AI52203, and R37AI44257).

The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2334/9/203/prepub All the studies discussed in this manuscript were supported by funding from Boehringer Ingelheim Pharmaceuticals , Inc

BMI – Body mass index; EQ-5D – EuroQoL-5 Dimensions; HRQoL – Health-related quality of life; RF – Risk factor; SHIELD – Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes; U.S. – United States; VAS – Visual analog scale SHIELD, the SHIELD Study Group, and the preparation of this manuscript were supported by funding from AstraZeneca LP.

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The development of this manuscript was supported by an unrestricted grant from Questcor Pharmaceuticals, Union City, CA. The supporter was not in any way involved in the development of the scientific content of this manuscript.

The manuscript was supported by the Theodor-Billroth-Academy® (TBA®) and INCORE, (International Consortium of Research Excellence) of the (TBA®).

This research and preparation of this manuscript was supported by Johnson & Johnson.

Preparation of this manuscript was supported by the National Institute of Mental Health Grants R34MH091284 and R34MH091384.

Publication fees for this manuscript are supported by the Teaching Hospital of Limoges, France.

Research reported in this manuscript was supported by the U.S. National Institute On Aging of the National Institutes of Health under award numbers R01-AG011552 and R01-AG040245.

The methodological argument we present in this manuscript is supported by analysis drawn from three distinct research projects we conducted in Luxembourg over the past five years, each of which utilizes video analysis, but with slightly differing approaches and foci.

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