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24 25 Results reported in this manuscript were prespecified, exploratory end points.
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For the delayed start design of the ADAGIO trial three primary endpoints were prespecified.
Stopping rules were prespecified for safety concerns, such as grade 3 or 4 adverse events.
All analyses were prespecified.
All comparisons were prespecified.
The eligibility criteria were prespecified.
All analyses were prespecified in the protocol.
All analyses were prespecified before trial completion.
The treatment comparisons tested were prespecified in the original protocol.
The methods were prespecified in the Cochrane review protocol.
18 19 The statistical methods used in this analysis were prespecified.
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