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Moreover, WNT11 is highly expressed in several cancers and cancer-derived cell lines, where it is implicated in proliferation, survival of progenitor-like cells, and migration and/or invasion12,13,15,20,21,22. In this manuscript, we further investigated the mechanistic link between WNT11 and cancer.
In this manuscript, we further develop the ideas of Pouso.
In this manuscript, we further investigated how MCa proceeds to cross biological membranes in order to reach its target.
In the analysis for this manuscript, we further identified a framework for the systemic barriers and facilitators as the World Health Organization (WHO) Social Determinants of Health model (Solar and Irwin 2010).
In this manuscript, we further demonstrate that solid-state incorporation (SSI) is a suitable alternative methodology for preparing highly active Sn-β catalysts.
In the revised manuscript we further suggest that mutating Arg228 may hinder the heterodimerization of EGFR and Her3 with Her2, but not the homodimerization.
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In this manuscript, we performed further studies in this human PeriA Tg mouse model to investigate the mechanisms of obesity-resistance and metabolic changes.
In the revised manuscript, we provide further details of the dimer interfaces observed in our MD simulations.
However, in the new manuscript, we cited further recent review articles that point to the role of hypothalamus in homeostatic regulation.
We accordingly altered our statement in the Results section, as the reviewers rightly indicate much of the data comes later in the manuscript, and we further added a few sentences in the Discussion summarizing the likely importance of distinct transcription factor induction patterns (in addition to MEK/ERK and PI3K dependence) to explain the observed differences at 4 hours.
In the new version of our manuscript, we have highlighted further these various aspects of the novelty of our work.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com