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Overall, we rewrote our manuscript to explain our new results in the context of prior studies (Abstract and Discussion).
We have revised the manuscript to explain this objective basis for the comparisons of buildup rates between the two conditions.
It was not the purpose of this manuscript to explain fully the role of KNa current during DRG electrical activity although that would have been nice.
A new figure has been added in the revised manuscript to explain the results and the detailed analysis is in Additional file 6. Minor point Comment: In the conclusions, the authors state "…the required transcription factor is significantly downregulated".
We have revised our manuscript to explain that Gli2 enrichment at the cilia tips is examined to reflect PKA activity (subsection "Regulation of Gli2 and Gli3 by Sema3-Nrp-mediated inhibition of PKA activity").
As detailed in the general comments and in response to Reviewer #3, we have revised the manuscript to explain better the biological implications, which are of major importance for the metabolism field, as they show that in co-growing cells, intermediate metabolism is substantially operating in a non-cell-autonomous manner.
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Hence, the present manuscript attempts to explain the development of metastable cellular microstructures during the SLM solidification process by considering the Bernard Marangoni driven instability (BMI) and particle accumulated structure formation (PAS) mechanisms, where both thermodynamics and kinetics play a role.
We have also added additional text to the manuscript to better explain these data and the points above.
We have re-written the manuscript to clearly explain the implications of using this drug to synchronize cells.
We have rewritten the manuscript to better explain the rationale of each single experiment and have made an effort to better link contiguous sections.
In this manuscript we attempt to explain the variances in outcomes of the RCTs of SGC and discuss the limitations of the current literature.
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