As the authors for this manuscript point out, virtually all of our previous "disaster plans, including those in hospitals were woefully inadequate and failed miserably [ 3].
One of the very first features I ever wrote rashly enquired why women dominated fiction but rarely wrote plays: I was deluged with letters, and manuscripts, pointing out the reasons were entirely circumstantial and determined by the fact the theatre was largely governed by male tastes.
But as the review of the original manuscript correctly points out, it is absolutely the case that this is not the only possible explanation.
We have added a sentence to the manuscript pointing this out (please see the subsection headed "Changes in synaptic activity alter the recycling pathway taken by AMPARs").
If anything, a credible critic, Gary Brenner carefully reviewed Mary's edits to the manuscript and pointed out that Mary apparently had cut out a lot of Hemingway's lengthy apology to Hadley that had appeared in every edition of the manuscript until the one that was published.
YI revised the manuscript and pointed out certain genetic links.
The reviewer highlights several misleading statements in the manuscript, specifically pointing out that: i) The amelioration of mutational damage through the bottleneck is a hypothesis; ii) Not all oocytes have heteroplasmy; iii) Discrete models of mtDNA populations do exist; iv) Statistical analyses of bottleneck mechanisms do exist.
One of the reviewers of the first version of this manuscript also pointed out 2 further publications, on which had not been found by my first search [ 14] and a second, which was a letter in the correspondence column of a journal, which included relevant information [ 15].
In the introductory paragraphs of this manuscript we pointed out that the signaling molecules associated with the presence of neuro-inflammation, seen in PD individuals are the same as those that are typically associated with cardiovascular inflammation [ 12, 33, 40, 42, 46, 69, 75, 88, 106, 306, 307] (see Figure 2 and Figure 3).
On the basis of this evidence, Connor concludes that Cockburn's dates would seem to have been altered by herself or Birch, as she would very likely have been older than 28 in order to have a grown son.In response to this, however, Anne Kelley, in her book Catharine Trotter points out that the manuscript version of this letter is a copy, not written in Cockburn's handwriting.
