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This step had three purposes: to maintain manuscript flow throughout the editorial process; to keep the main investigator masked; and to obtain a score for the initial quality, which was needed for subsequent random allocation.
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Manuscript flows among journals revealed a modular submission network, with high-impact journals preferentially attracting submissions.
To understand that it's not a panel of Pulitzer winners rejecting your creation, it's a 21 year-old intern who has the thankless task of sorting through the hundreds of queries and manuscripts flowing into their mailboxes every week.
The manuscript and flow diagram (Fig. 1) adheres to CONSORT guidelines.
G.H.K. and N.G. did the literature search and wrote the first draft of the manuscript, the flow chart and Table I.
We wish to thank Mary Davis for help with the manuscript; the University of Michigan Comprehensive Cancer Center UMCCCC) Flow Cytometry Core for flow cytometry analysis and cell sorting, and the Unit of Laboratory Animal Medicine (ULAM) for help with animal experiments.
SM and ARS wrote and revised the manuscript for logical flow and consistency.
The method outlined in this manuscript is a flow cytometric assay where gating is based on the difference in florescence of target cells before and after labeling with PKH67, a green fluorescent probe that gets incorporated into the plasma membrane of the target cells.
The old pattern of transmission regarding the Voynich manuscript would have flowed from academic research to peer review to publication to common knowledge (possibly via a TV program or two).
We thought that including these data in the manuscript could disrupt the flow of the manuscript.
We thank CM Croce for providing supports for microarray analysis, A Zeuner for providing useful materials, A Sorrentino for reading the manuscript, M Biffoni for flow cytometry, A Cerio for technical assistance, G Loreto for graphics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com