In addition, we now include in the manuscript estimated subjective hazard rates from both the leaky and bounded accumulator models for both tasks.
This manuscript also estimates KM for human ST3Gal-VI using Type-I and Type-II substrates.
The diffusion coefficient errors stated in the manuscript are estimates based on multiple calculations using different sets of simulations.
Based on the above and our experimental BMP data ([ 3], submitted manuscript), we estimate a varying cellulosic content between 60 and 80 %, depending on mentioned seasonal and influent fluctuations.
The archival holdings of Boston University, which include 60m manuscripts, are estimated to be worth close to $100m today.
In 2001 we carried out a similar study on 43 manuscripts to estimate the effect of reviewers, which was significant in several secondary variables, but not in the principal, although this did show a trend towards a positive effect [38].
CAD was involved in model development, contributed to the draft of the manuscript and provided estimates of BSE-infected animals.
(b) We have combined multiple panels in Figure 5 (of the revised manuscript), including Re estimates, comparison of incidence/prevalence in 2008 (previously presented as a panel with (a)), and a new panel showing cumulative cases as suggested in comment 3. (c) We have considerably reduced the length of the section on reassortment by removing any reference to MDS (and the figure) as suggested.
Authors' response: In the revised manuscript, we provide estimates of the changes in solvation energy of the cytochrome c upon its binding to Apaf-1 (ΔG s ) for all model structures that were obtained after energy minimization, as well as for the model structure by Yuan et al. [ 25 ]; the results are presented in the new Table 2 and discussed.
Beowulf The most important work in Anglo-Saxon literature, the Old-English epoempofm of 3,182 lines is known from a single manuscript that is estimated to date from AD1000.
