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A structured manuscript developed by advanced students has been well received by junior students and was very valuable in a formal structure environment [ 10].
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The present manuscript has been developed by the authors who gathered and summarized the data.
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For clarity, we use throughout this manuscript the convention developed by Stefansson et al. (13) and refer to the two structural configurations relative to the order represented in the human genome reference assembly.
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The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2474/15/172/prepub The authors hereby declare that the novel methods presented in the manuscript has been entirely developed by dr Ahmed Elsaftawy.
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