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IL and LL aided in writing the manuscript and evaluating the proposed methods.
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ØS participated in the design of the study, drafted the manuscript, and evaluated patients for inclusion and follow-up exams.
GEP drafted the manuscript and evaluated hydroxyurea data previously published in antiretroviral studies described in Background and Discussion.
RAD, RS, JAM, GJD and JRS assisted MAB in the interpretation of the results, the drafting of the manuscript, and critically evaluating earlier drafts of the manuscript.
AB helped in drafting the manuscript and critically evaluated it for the intellectual content.
CTS assisted in design, interpretation of results, drafting the manuscript and critically evaluated earlier drafts of the manuscript.
UW, JJR, CvdV assisted CS in interpretation of results, drafting the manuscript and critically evaluated earlier drafts of the manuscript.
YK (Kawashima) has been involved in planning of study, collection and evaluating data and manuscript writing.
Authors' response: We agree that these are important conditions for the validity of the hypothesis, and have modified the manuscript to acknowledge and evaluate these issues (see above and in the revised manuscript).
In this manuscript we develop and evaluate a set of imputation strategies for dealing with nongeocoded addresses so that analysis can proceed using all case records.
In this manuscript we develop and evaluate a set of imputation strategies for dealing with missing spatial information from nongeocoded addresses.
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