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We also corrected the confusing descriptions through the manuscript, and emphasized that KCBP acts as a central player or a hub protein to assemble the required cytoskeletal configuration for trichome branching and highly polarized branch elongation accompanied by tip sharpening.

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Quantifying input noise between 1-NM-PP1 and Msn2: We thank the reviewers and the editor for carefully reviewing our manuscript and emphasizing the crucial point regarding Msn2 input noise, and also for being very clear about which experiment they would like to see performed.

To expand and emphasize this point, we have included additional data in the revised manuscript that support this conclusion.

The manuscript states (in the Results section) that neuronal responses encoded forced and free choices similarly, and emphasizes that this result was not necessarily expected.

In the revised manuscript, we have emphasized the control aspect of the XFEL work and de-emphasized its role in general.

In the revised manuscript we have emphasized the probable role of protonation states of acidic residues in the binding site in pH-dependent activity changes.

We clarified this further in the manuscript by emphasizing that ps is low, and defining what symmetric and asymmetric division mean.

We have used the "gene-centric" definitions introduced by Elowitz (Elowitz et al., 2002) and we have re-written large sections of the manuscript to emphasize the analysis of information loss due to "gene-intrinsic" and "gene-extrinsic" sources.

Although the manuscript emphasizes M1 and PMC, dissociations between spatial and temporal coding were observed in other areas (PPC and ACC) and warrant further consideration.

We have restructured our manuscript to emphasize the correlations between relevant confounding factors and GC content variation.

We have updated the text to clarify the state of our understanding and we changed the title of the manuscript to emphasize other aspects of this work that are more central to the novel and important findings described herein.

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