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She said she used fact checkers for the manuscript and added that she has answered most of the charges either by letter or by telephone.
ST critically revised the manuscript and added important intellectual content.
TL and MLR reviewed the manuscript and added inputs for improvement.
AM revised the manuscript and added some of the related works, helped finding bugs and revised the code, adapted the local regression algorithm and performed some of the experiments and statistical analysis.
She revised the manuscript and added important intellectual content.
ER, BR, DB and MM all critically reviewed the manuscript and added parts to the text.
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BMD was responsible for reviewing the manuscript and adding valuable comments to it.
An alternative suggestion would be to move this figure at the end of the manuscript and add also siDHX36.
Ryan et al. (2014) expand the discussion of our manuscript and add insight into the possible pathogenic mechanisms that predispose GCH1 loss-of-function mutation carriers to nigrostriatal degeneration.
While it would not seem reasonable to add a lot of experiments at this point to address this question, an extended self-critical discussion would be required (i.e., extending the self-critical assessment throughout the manuscript and adding also a word of caution into the Abstract).
LYT: surgical operation, drafting the manuscript; LH: helped to draft and edit the manuscript; CKY: carried out radiological intervention; WHS: involved in the clinical management of the patient; HMH: revised the manuscript critically and added substantial intellectual content; YSL: final review, supervision of scientific content of manuscript.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com