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However, the complex synthesis of this polymer leads to variations in the structure and consistency of the final product, and makes scale-up of manufacturing difficult.
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Despite a growing demand for these products, manufacturing remains difficult and costly.
With traditional polymeric flocculants, not only a narrow operating window on flocculant dose accompanied by inherent variation in cell culture makes development and manufacturing operations difficult but also free residual polymer molecules remaining in the culture after flocculation and clarification demand a strategy for monitoring and clearance (Fig. 4A).
However, the dynamic and complex concepts and phenomenon in manufacturing processes are difficult to teach and comprehend using stationary pictures and verbal explanation.
Though this is an interesting and impressive development, it would be a potentially costly and difficult manufacturing step if necessary for satisfactory device operation.
Manufacturing is difficult and costly, said Dr. Hal Barron, vice president of medical affairs at Genentech.
Very few consumers ask: where is the engine built or where is the transmission made?" Assessing the quality of Chinese manufacturing is difficult, partly because of the design of this particular engine.
However, its fabrication through laser-based additive manufacturing is difficult to achieve.
But the actual manufacturing was difficult.
According to an official with the Bureau of Alcohol , Tobacco Firearms and Explosives, manufacturing C4 is not difficult for any nation capable of making industrial chemicals.
Achieving such manufacturing goals will be difficult because the silicon chip and package must be built up simultaneously instead of being produced separately as they are today.
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