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In order to improve ToP reconstructions, we manually studied the lifestyles of cellular organisms in the total dataset and excluded organisms exhibiting parasitic (P) and obligate parasitic (OP) lifestyles, as their inclusion is known to affect the topology of the phylogenetic tree [ 29].
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Lastly, we assessed the functional coherence of the clusters by manually studying their annotations and their GO Steiner trees.
The burn-in phase was defined manually by studying carefully the output of TRACER.
The amino acid sequence delimited by each AnABlast peak was further studied manually by using BLAST and Pfam from their web applications (https://blast.ncbi.nlm.nih.gov/ and http://pfam.xfam.org/, respectively).
Unlike previous studies that read the ECG recordings manually, our study used a predefined computer algorithm that automatically detected beat labels and QTc intervals to analyze ECG recordings.
Nonetheless, this might not be the case in manually assembled camera rig studied in this paper.
For each genome, some subsets of genes are manually annotated and thoroughly studied.
References and cross-references of the articles were critically studied through manually to find any relevant study missed by the electronic and/or manual search.
In this study only the trabecular bone of the condylar process was studied by manually drawing the region of interest to separate the trabecular bone from the cortical bone.
All the articles were reviewed manually for study design, population, outcomes, and study quality.
An easy-to-use web interface distributed with the layout software allows the user to query and navigate layouts that are too large to study manually.
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