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Third, terminological cycles and inconsistencies are manually eliminated and, in the last step, the knowledge base built this way is incrementally refined by a medical expert.
After automatic spot detection, artifacts such as dust or cracks on gels were manually eliminated, and then the weaker spots (individually < 0.05% of the whole gel volume) were eliminated.
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From papers so collected, we manually eliminated duplicate citations and those that did not meet the above criteria.
Second, all determinants were put in one model and manually eliminated by stepwise backward regression.
Since the KH Coder calculates word frequencies without analyzing the full context, some misclassifications were observed and manually eliminated when calculating this proportion of cases in each topic.
These structures likely represented dura and cortical arteries, veins, and sinuses and were thus manually eliminated (Fig. 5).
Therefore, for the first step of selecting images, we manually eliminated the images with dark background and uninformative images (Supplementary Fig. 4) from the training set.
Poorly aligned regions and gaps were manually eliminated.
Null alleles were suggested to be present at two loci (D14s306 and D6s474), so we manually eliminated all apparent homozygotes at both loci by replacing one allele by a missing value.
The sequences were aligned using MAFFT 7.164b with the L-INS-i option49, and poorly aligned regions were manually eliminated using MEGA 6.050.
Genes with a fold change (FC) of ≥ 3.0 between the spl5 mutant and the WT were identified as the differential expression genes, but those which have poor microarray signals with the Flag value of A (absent) or with the normalized intensity ≤ 500 were manually eliminated.
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