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Therefore, it is challenging to manually design a robust encoding filter to face the complex intra-class variations of heterogeneous iris images.
Many previous works manually design regularization to simultaneously estimate the latent sharp image and the blur kernel under maximum a posterior framework.
A pharmacophore hypothesis can be used to manually design new compounds or to search a database to find molecules that contain the required features.
If you manually design, you put every row at same tilt and configuration.
Their approach required a considerable amount of effort and knowledge to manually design patterns that were later used to generate grammatical test items (Chen, Liou, & Chang, 2006).
We chose the machine learning approach because it is hard to manually design features for classification that are general enough for reliable differentiation between primary particles and agglomerates in various particle constellations.
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If no CAPS were previously designed from our SNP set, CAPS markers were manually designed with CAPS Designer (http://solgenomics.net/tools/caps_designer/caps_input.pl) and Primer3Plus (http://www.bioinformatics.nl/cgi-bin/primer3plus/primer3plus.cgi/).
When the sequences are manually designed this knowledge comes from a human brain, aided by manual lookup of literature and databases.
Unlike existing feature-based methods, this approach does not rely on any manually designed features.
The network topology was manually designed, and then modified in response to observed difficulties during evolution.
Therefore, NerOne automatically combines the components instead of using manually designed rules.
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