Lesions were defined manually as described in Geva, Baron, Jones, Price, and Warburton (2012).
This initial alignment was refined manually (as described in Methods) to remove redundant sequences.
Adenomas were counted manually as described in the materials and methods section using a dissecting microscope.
Genotypes were automatically called with the SpectroCALLER software (Sequenom), and manually checked as described in Silander et al [32].
Transcription start sites (TSS) were manually identified as described in Passalacqua et al. [ 4].
The alignment was manually truncated as described in the Results and Discussion section.
All mutations were manually verified as described in the Materials and Methods.
*The occurrence of novel gypsy-like and copia-like elements (underlined) was manually examined as described in the text.
Averaged signal ECGs were generated by aligning R waves of >200 complexes from lead I and analyzed manually as previously described in detail [ 26].
A random sample of 1000 of these cases was manually reviewed as described in the methodology and an index list created from relevant terms.
