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The most frequent class candidate terms were then manually defined in the chemical ontology via SMARTS expressions.
In addition, the Information Delivery Manual (IDM) that includes exchange specifications needed for each exchange process of a product model is manually defined in a paper-based document.
A three- dimensional region of interest (ROI) was manually defined in each mouse for the tumor using the last time frame (110 120 min) of the PET image with a threshold of one-half of the maximum SUV of the tumor.
The ROI was manually defined in each case by an expert physician.
Landmarks were also manually defined in the gel to increase the accuracy of the spot matching algorithm.
The regions of interest (ROIs) were manually defined in CC, IC, GM, and muscle areas from each hemisphere using MATLAB, avoiding regions of banding artifacts (N = 4 hemispheres for each group).
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Manually defined domains in our database are of three alternate categories (613 "by structure", 612 "by sequence", and 58 "composite").
b Measurement of bowel wall vascularity after second generation contrast agent injection in a manually defined ROI localised in the ileal wall.
In order to investigate another reference region we also manually defined a VOI in the cerebellum, which is frequently used as a reference region in clinical [C]PK11195 or [I]iodo-PK11195 studies of Alzheimer's disease [ 25– 27].
An error in a manually defined detection rule stays in the system until an expert finds and corrects it.
9) The authors should explain clearly how they manually defined their ROI in the substantia nigra and other small structures (only names of anatomical atlases are specified in the Methods), and extensively discuss the inherent limitations coming with such a resolution for both their seed-based analysis and propagation model.
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