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Regarding enzyme loops classifications: ArchDB-EC contains 20260 loops in 1338 classes and 2686 subclasses and ArchDB-KI has detailed functional information that has been manually curated; up to 76 out of the 203 subclasses (37%) contain residues with functional annotation collected from the literature.
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These references are manually curated with up to 10 key references that may also include older references not indexed in PubMed.
The video chat and messaging app includes a child-friendly selection of augmented reality lenses, emoji, stickers and manually curated GIFs for spicing up family messaging.
These, plus six additional paralogous loci, were manually curated and defined using up- and down-stream sequence in order to enable the BIGSdb scanning function to correctly distinguish the divergent regions of the paralogous genes without manual curation.
In NCI-PID, 137 human pathways (or 9248 Interactions) are manually curated by NCI-PID administrators (up to September 2012), whereas 322 human pathways (or 7575 Interactions) are directly imported from BIOCARTA and REACTOME databases.
We first confirmed the observation of modular essentiality in S. cerevisiae using an up to date manually curated set of "gold-standard" protein complexes (Pu et al. 2009) and the method of Hart et al. (fig. 1, see Materials and Methods).
In case new experimental evidence on nucleotide-sugar biosynthesis becomes available that refutes the predicted results, the database will be manually curated to keep it up to date with the most recent experimental findings.
However, due to limited human resources, manually curated databases cannot always be kept up-to-date.
In the case of such overlap, the sequences were assembled to build up a contiguous genomic and transcript sequence and subsequently manually curated to identify open reading frames and protein sequences.
As accession numbers for mature miRNAs were introduced only in release 6.0, files up to miRBase release 5.1 were manually curated to match (later) accession numbers.
The result is a highly curated database of chemical structures with their associated manually curated identifiers.
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