The "habitat" of each microbe with a genome in the SEED platform was manually curated from Bergey's Manual of Determinative Bacteriology [41].
Sequences were then queried using BLASTn against a highly curated custom database of high quality 16s bacterial sequences derived and manually curated from NCBI.
GeneSigDB (http://www.genesigdb.org or http://compbio.dfci.harvard.edu/genesigdb/) is a database of gene signatures that have been extracted and manually curated from the published literature.
All binding affinity data in PDBbind are manually curated from nearly 24,000 original references.
Mass Frontier (see below) currently contains the largest fragmentation library, manually curated from several thousand publications [33].
The current release of database has data of 2401 rice proteins manually curated from 538 research articles.
Currently, it holds 2582 entries including 188 plant families (692 genera and 808 species) from global flora, manually curated from literature.
The main database, StARLITe, on Drug-Target interactions alone has hundreds of thousands of interaction data points manually curated from the medicinal chemistry literature.
A further dataset was manually curated from the PDB to guide the generation of a map of the structures of diverse and therapeutically relevant potential small molecule binding sites.
In addition, we manually curated from the literature and 17 new miRNA-target pairs for which the functions have been well studied.
Especially, the LC data were manually curated from over 31,793 abstracts and online publications [41], and there is no interaction derived from standard large-scale experiments in both FYI and HCfyi.
