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For creating the feature database, the 1299 snake images are manually converted by taxonomist to form feature vectors representing 38 taxonomically relevant features.

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Currently, all the symbols within a map can only be manually converted one by one, which is not only laborious and time consuming but also burdensome, and one needs to understand the meaning of each symbol within the map in advance.

The chemical structures contained within these images were manually converted to SMILES strings, chiefly by redrawing the structure using ChemDraw 12.0 and exporting the structure as SMILES or by manual conversion in the case of simple structures, which were recorded in an index of the corpus.

Images of dendritic networks (MAP2 staining) were manually converted into graphs (Figure 3a1,2) by implementing a graph deduction paradigm similar to the one used by Shefi et al. [17], where vertices were marked mainly at dendro-dendritic intersections, cell bodies, bifurcations, or growth cones (Figure 3a1,2).

For instance, in [28] the floating-point model is manually converted into a hybrid code model by defining fixed-point word widths at some "important" locations; the remaining floating-point values are then interpolated by analytical means.

Then gene symbols were converted to Entrez Gene IDs by IDConverter [ 64] (a few genes not transferred by IDConverter were manually converted).

Questionnaires returned by post were manually converted to a Word document, double checked and processed in the same was as the digitally returned questionnaires by the first author (EMH).

Since TA Instruments use a positive sign for an exothermic reaction, which is opposite to the conventional presentation used by MicroCal (GE), we manually converted the measured raw data that are presented in all figures.

MIRU-VNTR allele number was manually converted according to amplicon size.

The significance of comparison among diversity indexes were accessed by a two sample z-test for comparison between means [ 78]. fru C3 exon and I3 intron haplotype networks were inferred by TCS v 1.21 software [ 79] using statistical parsimony with a 95% connection significance [ 80], and was manually converted to Newick tree format for some of the neutrality tests.

We organized these data by manually converting different identifiers in publications to the unique National Center for Biotechnology Information (NCBI) Entrez/Gene ID.

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