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In our experiment, the ground truth (GT) of the IMT was measured by expert vascular clinician, which was manually computed by delineating the LII and MAI boundaries on the ultrasound images for six times and then averaged.
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We have recently presented an automated method [5] based on the clinically validated methodology for manually computing BSI as presented by a group at the Memorial Sloan-Kettering Cancer Center in New York [3, 8, 9].
The involved partial derivatives are either manually derived or computed by algorithmic differentiation.
A researcher can manually compute sample size using these formulae.
Given that recall requires knowledge of all relevant pages on a given topic (an impossible task in the context of the Web), it is computed by manually designating a few representative pages on the HME domain and measuring what fraction of them are discovered by the crawler [3].
The TIV was computed by manually tracing the entire intracranial cavity on 7 mm thick coronal slices, by the use of the software DISPLAY 1.3 tools.
Once the point of initiation of a burst was entered manually, the amplitude was computed by finding the maximum of the signal automatically.
The outline of the aortic surface and lesions were defined manually by a blinded observer, and lesion areas were computed by an image analysis program (BioPix Software, Göteborg, Sweden).
The plasma membranes of individual adipocytes were defined manually by a blinded observer, and adipocyte surface areas were computed by an image analysis program (BioPix Software).
In our experiment, the mean difference of AS and GT is 0.0231 mm among the 93 correctly tested images; that is, the IMT computed by our technique is more likely thicker than that manually measured by expert.
Lists of the annotated regions can be found in Additional file 2. For the results presented in this paper, only the list of DMRs computed by subtraction of tumors from controls (hypermethylated DMRs) was manually mined for the candidate biomarkers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com