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Kegg-pathways and Reactome contain manually annotated pathways of processes of biological interest.
Complementary to the computationally composed pathways, a number of manually annotated pathways are provided.
The KEGG database contains manually annotated pathways based on biochemical evidence from the literature, including metabolism, genetic information processing, environmental information processing and cellular processes.
On the EndoNet's web interface graphical representations are limited to the manually annotated pathways and the path analysis of at most 20 pathways.
The path analysis on the EndoNet webpage outputs all shortest paths between two nodes independent of any circumstances, whereas the manually annotated pathways (mainly endocrine axes) are limited in number and restricted to already known pathways.
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We used the GENIA corpus [ 26] to generate a subset of abstracts with manually annotated pathway mentions.
We also put efforts in increasing the number of manually annotated hormonal pathways to a total of 9 now, which is a particularly time-consuming task.
The manually drawn and annotated pathway maps represent knowledge about the metabolism, genetic information processing, and cellular processes.
We also excluded KEGG "cancer" annotated pathways.
It provides manually annotated metabolic and signaling pathways.
Our gold-standard corpus was derived from GENIA in two parts, which are both manually annotated for mentions of named pathways.
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