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Currently, this process involves manual data curation and expert judgements of the data content.
With an attempt to speed up and improve the efficiency of manual data curation, a prototype text-mining application has recently been developed to prioritise the available literature [32].
As will be described in more detail towards the end of the paper, manual data curation has distinctive advantages (and disadvantages), which will prompt us to suggest an approach inspired by Wiki and social networking software, towards enabling manual curation at a larger scale, for maintaining and updating the PluriNetWork without resorting to machine learning or text mining.
RW investigated unknown transcripts, performed manual data curation, validation experiments and analyses and wrote the manuscript.
Manual data curation is very central to the contemporary biomedical research, as it generates computable data that is accessible to both machines and end users.
The new ontology search, browser and report features have been designed to enhance both manual data curation and manual data extraction.
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Recently, there is a growing interest for building automatic text-mining tools to assist manual biological data curation (eCuration) (9 20), including systems that aim to help database curators to rapidly and accurately identify gene function information in full-length articles (21, 22).
Thus a manual data retrieval and curation was necessary to test the constraint-based atom mapping approach presented above.
Automating steps in the manual data entry process can improve curation efforts for major biological databases.
Manual data preparation and entry constitutes 13% of the curation effort in the FC dataset.
The masked alignments produced by STAP's automated process agreed well with those produced by our manual curation (data not shown).
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