The first few decades of computer modeling focused on the physics of radiation absorption in human tissue relative to the geometry of radiation beams produced by then current machinery, and on the design of interactive systems that could be used for manual computer aided design.
Based on a manual computer record review, we classified 73 of 2,025 (3.6%) as severe hypoglycemic episodes, defined as leading to an emergency hospitalization and/or to death.
Though such fully automated systems are not yet on the market, semi-automated and manual computer systems incorporating these CAD systems are relatively widely used, with several clinical publications already reporting on their usage.
Total vessel density (TVD) was assessed in parallel using manual computer-assisted image analysis as well as a fully automated analysis pathway utilizing a newly developed computer algorithm.
Manual computer-assisted video analysis revealed no influence of topical application of ACH to the sublingual mucosa on TVD or the blood flow velocity within the venules as quantified by space-time diagrams.
The video files were analyzed in parallel using manual computer-assisted image analysis representing the current gold standard [34], as well as a fully automated analysis pathway utilizing a newly developed computer algorithm.
In addition, we have employed manual computer-assisted video analysis as well as introduced an objective and reproducible algorithm for the analysis of capillary microscopy videos, (III) yielding moderately comparable results.
As a secondary aim, we have tested whether (III) the intervention induced changes in TVD and microcirculatory flow velocity can be detected both by manual computer-assisted video analysis representing the current gold standard, as well as a newly developed, fully automated algorithm for microcirculatory video analysis.
In order to test our hypothesis, we have examined 41 healthy subjects using incident dark field video microscopy and assessed TVD and microcirculatory flow velocity before and after the topical application of ACH and NG both by manual computer-assisted video analysis and by a newly developed, fully automated algorithm.
Methods have also been developed to quantitate MPD, including manual, computer-aided, and fully computerised methodologies (Byng et al, 1994; Boyd et al, 1995; Zhou et al, 2001; Wei et al, 2004; Martin et al, 2006).
Students work fluidly between manual drawing, computer drawing, and material construction.
