The consequence could be quite negative that the optimization process generates unsatisfactory or even useless design solutions and tedious manual efforts are required to modify or even redesign the immature solutions, which reduces the overall design efficiency and quality.
Such manual tracking is slow and tedious.
Besides being subjective, prone to error and tedious, this manual approach is becoming increasingly infeasible: upon completion, FIRST will include almost a million galaxies.
The solution has been legislation to improve standards of health, safety and benefits etc, not to make heavy manual work, tedious factory work and street cleaning, for example, all illegal.
Manual counting of total RGCs is time consuming, labor intensive, and tedious, with potential vulnerability to bias.
Even for known complexes, manual selection of ∼100 000 single-particle images is prohibitively time-consuming and tedious.
Current manual methods of converting crystal structures into 3D printable files are time-consuming and tedious.
However, to build such models, pharmacological data must be collected for both targets, which is a tedious task, often involving manual and poorly reproducible steps.
This manual inspection is tedious and time-consuming.
The manual process is tedious and error prone.
