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NDGA reduces weight in a dose-dependent manner without change in food consumption, suggesting it either decreases absorption or increases caloric utilization (Spindler et al., 2014) NDGA was not overtly toxic in mice, but was associated with increased liver, lung, and thymus tumors, as well as peritoneal hemorrhage (Spindler et al., 2014).
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Stat3 phosphorylation was significantly reduced by salinomycin in a dose-dependent manner without changes in total levels of Stat3.
In addition, hexachlorobenzene increased the activity of hepatic T4 UDPGT in a time-dependent manner without changes in T3-UDPGT (Alvarez et al. 2005).
Firstly, the DNA of the organism is changed in a specific, predetermined manner, without changing other parts of the genome.
Recently, it has been demonstrated that acute exercise training altered cardiac protein O-GlcNAcylation in a very time- and spatial-restricted manner without any change in overall O-GlcNAc protein levels (136).
Our data reveal that biphenyl-ether derivatives bind noncovalently to the proteasomal tryptic-like active site in a reversible substrate-like manner without allosteric changes of active site residues.
The method demands that the building will continuing to be used in the same manner, without structural changes or shifts in usage patterns.
Studies investigating CLA-producing probiotic strains have demonstrated that Lactobacillus rhamnosus PL60 and Lactobacillus plantarum PL62 reduce body weight and adipose tissue mass in mice on a high fat diet in a CLA-dependent manner, without any changes in food intake.
The Acceptance component of ACT involves exercises to help the person recognise the futility of trying to directly suppress and control such experiences, combined with teaching skills in mindful observation of experiences in a detached manner without attempting to change or judge them.
As dynamic structural changes are pivotal for the functions of some classes of RNA molecule, it is important to develop methods to monitor structural changes in RNA in a time-dependent manner without chemical modification.
ETC-1002 was also shown to activate AMPK in a Ca2+/calmodulin-activated protein kinase kinase β (CaMKKβ -independent and liver kinase β (LKB1)-dependent manner, without induCaMKKβ -independentnges in andnyliverenergy charge (AEC).
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