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Our results showed that GVBD in cumulus-enclosed oocytes (CEOs) but not in denuded oocytes (DOs) was induced by EGF in a dose-dependent manner, which indicated that cumulus cells but not oocyte itself were the main target for EGF-induced meiotic resumption.
However, CAF treatment increased glycerol secretion in a dose-dependent manner, which indicated that CAF strongly stimulated lipolysis in differentiated 3T3-L1 adipocytes.
After co-incubation with 25 ~ 100 μg/ml apoptotic DNA fragmentation for 24 hours, the expressions of α-SMA in HSCs were unregulated in a dose dependent manner, which indicated apoptotic hepatocyte DNA stimulated HSCs activation.
Corin and ANP expression was decreased with high glucose treatment in a time-dependent manner, which indicated that the changes of corin and ANP levels were associated with the course of diseases.
The MTT assays showed that icaritin significantly inhibited the growth of both cell lines in a dose-dependent manner, which indicated that icaritin has antitumor activity on lymphoid malignancies such as Burkitt lymphoma.
Strikingly, we also found that increase of Bax/Bcl-2 ratio, Δ ψm dissipation, release of cytochrome C, and cleavage of caspase-9 after exposure to 5-ATAN in a time-dependent manner which indicated caspase-dependent intrinsic pathway were also required in the MCF-7 cells [ 39].
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Worryingly for their new manager Chris Hutchings, they succumbed in a manner which indicates they will face another season of struggle.
Some stress-induced genes were regulated in a tissue-specific manner, which indicates that these genes may play roles as part of distinct mechanisms for coping with drought stress.
Moreover, we found that SE treatment inhibited the CCl4-induced hepatic TNF and IL-1ß expression in a dose dependent manner which indicates reduced activation of Kupffer cells, the resident macrophages in the liver, and less hepatic immune cell infiltration, respectively.
Indeed, NFAT was coimmunoprecipitated with NR2F6 in a DNA scaffold dependent manner, which indicates that these two TFs form a heterodimeric protein:protein complex when bound on DNA.
The T1s/ T1ns values decrease in a concentration-dependent manner, which indicates that the apparent τc of SKF in solution is larger at higher concentrations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com