Sentence examples for manner we hypothesized from inspiring English sources

As extracellular ligands such as Dlk1 commonly exerts their effects on neighbor cells in a cell-contact dependent manner, we hypothesized that Dlk1 over-expression non-cell autonomously regulates myoblast proliferation and differentiation.

If the HCF-1 Basic region is indeed plastic owing to multiple redundant elements spread throughout the region that act in a cumulative manner, we hypothesized that residual activity in the N- or C-terminal halves of the Basic region (Fig. 2) might be amplified by tandem duplication.

Since SAPs had been shown to reach the lysosomes in an M6P-R independent manner, we hypothesized that sortilin was the sorting receptor for SAPs.

As tamoxifen downregulates E6AP and induces C/EBP α expression in cell-type-specific manner, we hypothesized E6AP might be an E3 ubiquitin ligase for C/EBP α.

Strikingly, biology faculty grouped cards together in a manner we hypothesized experts would, grouping cards primarily based on deep features (fundamental biological principles).

To understand how Kri1l deficiency-caused ribosome defects trigger excessive autophagy via a p53-independent manner, we hypothesized that impaired ribosome biogenesis might cause dysfunction in protein synthesis to trigger misfolded protein accumulation, which is known to activate autophagy.

Given that K4eRNA expression positively correlates with Klf4, responding to NANOG and LIF/STAT3 in the same synergistic manner, we hypothesize that K4eRNA is a cis activator of Klf4 transcription.

In order to fully utilize the complete repertoire of cytokines secreted by activated lymphocytes in a simple yet effective manner, we hypothesize that nonspecifically-activated CD4+ lymphocytes (aCD4) can pre-sensitize tumor cells to enhance the apoptotic effect of gamma radiation.

Because TNF-α secreted from tumor cells and/or macrophages can affect the phenotype of these cells in a paracrine and/or autocrine manner, we hypothesize that colorectal cancer cells may interact with TAMs in the microenvironment and alter the cytokine profile of TAMs to promote tumor progression and metastasis through TNF-α, the secretion of which is stimulated by PRL-3 in a paracrine manner.

In conclusion, we have found that wound healing factors can stimulate HNSCC cells to increased aggressiveness in a cell-line-specific manner, and we hypothesize that such cellular changes could affect the propensity for certain tumors to establish local recurrences after surgical excision.

Duplicated genes are frequently silenced either throughout the plant or in a tissue-specific manner [ 52- 55]; hence we hypothesized that one or more of the copies of each gene could be significantly down-regulated.