We found that sesB is a negative regulator of autophagic flux, and Dcp-1 interacts with sesB in a nonproteolytic manner to regulate its stability, uncovering a novel mechanism of mitochondrial associated, caspase-mediated regulation of autophagy in vivo.
They also suggest that Set2 and Dot1 might function in antagonistic manner to regulate cellular response to DSB.
DCAR-1 acts in an epidermis-specific and cell-autonomous manner to regulate the induction of nlp-29 AMP gene.
Miyashima, S., Koi, S., Hashimoto, T. & Nakajima, K. Non-cell-autonomous microRNA165 acts in a dose-dependent manner to regulate multiple differentiation status in the Arabidopsis root.
We have extensively examined how TGF-β1 effects are mediated by the distinct TGF-β receptors via activation of intracellular signaling molecules downstream to the receptors in a cell-specific manner to regulate cellular responses in renal cells.
Previous electrophysiological studies have proposed that these dopaminergic neurons may release endocannabinoids in an activity-dependent manner to regulate their various synaptic inputs; however, the underlying molecular and anatomical substrates have so far been elusive.
The innate and adaptive immune cells in the TME interact among themselves and also with the endothelial cells, pericytes and mast cells of the stromal compartment through various autocrine and paracrine manner to regulate abnormal cell proliferation.
Taking advantage of the conditional knockout mouse model, we show here that endogenous oxytocin signaling functions in a non-cell autonomous manner to regulate survival and maturation of newly generated dentate granule cells in adult mouse hippocampus via oxytocin receptors expressed in CA3 pyramidal neurons.
Together, our loss-of-function and gain-of-function studies suggest that Sox2 functions in a dose-dependent manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud sensory cells versus keratinocytes.
Several positive and negative transcription factors function in a concerted manner to regulate the transcription of cytokine genes to initiate immediately on activation and to shut down quickly, even in the continuous presence of the stimulating agent [38].
Another line of evidence shows that IRG proteins accumulate on the T. gondii vacuole in a cooperative manner to regulate anti-parasitic Irga6 function [36].
