Sentence examples for manner to mediate from inspiring English sources

For instance, Ras binds RASSF1C in a GTP-dependent manner to mediate apoptosis [ 25].

In mice, multiple Hes genes function in a redundant, gene dose-dependent manner to mediate canonical Notch signaling.

Then, monocytes recruit neutrophils in a TLR7 -dependent manner to mediate focal necrosis of endothelial cells, whereas the monocytes remove cellular debris.

These molecules are produced within the mammary tissues proper and they act over very short distances, often in a paracrine manner, to mediate functional interactions between the stromal and epithelial compartments of the gland [ 63].

These lncRNAs appear to function near their site of synthesis, in either an RNA-dependent manner to mediate looping onto the promoter regions of their transcriptional targets, or by using RNA-independent mechanisms to locally alter chromatin status.

Interestingly, our results suggest that cBAF functions downstream of Aplnr signaling, in a cell-autonomous manner, to mediate the migration of cells to the heart-field region of the developing embryo.

Distinct binding events occur in an ordered manner and cooperate to mediate the assembly of the active Cyclin A-Cdk2 complex and subsequent docking and phosphorylation of Cdc6.

This molecule was shown to interact with both ADIPOR1 and ADIPOR2 in an adiponectin-sensitive manner, and was shown to mediate many of adiponectin's insulin-sensitising effects.

More recently, aberrant expression of splicing isoforms of BRAF (V600E) that dimerize in a RAS-independent manner has been shown to mediate acquired BRAF inhibitor resistance.

Moreover, RfBP adopts a ligand-receptor binding manner [ 13, 31, 32] to mediate riboflavin translocation into the growing embryo [ 25].

Thus, the K present in loop 8/9 undergoes conformational switching in a ribosome-dependent manner; therefore, it is likely to mediate the interaction between GlSec61α and the ribosome.