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In the 1970s, Langer went on to develop polymer materials that allowed the large molecules of a protein to pass through membranes in a controlled manner to inhibit angiogenesis, the process by which tumors recruit blood vessels.
Besides, we utilized the emerging technology of medical synthetic biology to design tetracycline-inducible small hairpin RNA (shRNA) vector which specifically silenced HIF1A-AS2 in a dosage-dependent manner to inhibit the progression of human bladder cancer.
Intriguingly, different IAP proteins may interact with a variety of pro-apoptotic proteins in tissue specific manner to inhibit apoptosis induced by diverse signals.
Targeted nanoparticles induce expression of a CXCL12/SDF-1 trap in a transient and liver-specific manner to inhibit colorectal cancer liver metastasis.
However, in bone marrow derived macrophages CpG-antagonist act in a TLR-9 independent manner to inhibit Salmonella killing [39].
An immediate "deliverable" to biologists is an easy to follow 3D in virtuo model which explains how TGF-β1 acts in wound healing in a highly coordinated manner to inhibit cell proliferation and stimulate cell migration.
Similar(33)
Synthetic peptides, derived from the deduced amino-acid sequence encompassing this region, were examined for their ability to bind calmodulin in a calcium dependent manner and to inhibit the Ca2+/calmodulin-dependent autophosphorylation of CaM-K II.
In another study, Skp2 ablation in Rb1 +/− mice blocks spontaneous tumorigenesis in a p27-dependent manner, but fails to inhibit tumorigenesis induced by a chemical carcinogen, ENU.
Hence, fish oil altered lipid mediated signalling in a dose and time dependent manner so as to inhibit progression of colon cancer.
However, they also act in an inhibitory manner through motor neurons to inhibit egg-laying [ 40].
Moreover, it shows that ADAMTS1 acts in a paracrine manner on endothelial cells to inhibit cellular proliferation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com