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Areg promotes neoplastic growth in mammary epithelial cells, fibroblasts, and keratinocytes [29], [30] and was shown to function in an autocrine manner to drive the proliferation of malignantly transformed cells of colon, breast, cervix, prostate, and pancreas [31].
Importantly, since K-Ras oncoproteins differentially promote transformation, cell migration, and anchorage-independent growth, they most probably act in a cooperative manner to drive neoplastic progression [ 10].
In summary, we showed that TAK1 deficiency increases CTF by a ROS-dependent manner to drive EMT in metastatic A5RT3 cells.
How do factors like Myod activate their transcriptional targets in a temporally and spatially controlled manner to drive cell-type-specific, or fiber-type-specific, differentiation?
One possibility is that multiple MBD proteins may function in a redundant manner to drive H3K9me to regions containing DNA methylation.
Hence, Hox4 genes are required in a dose-dependent manner to drive apical enlargement on both sides of the murine r6/r7 boundary.
Similar(53)
Valery Gergiev thrills a lot of critics, but his helter-skelter manner seems to drive American musicians to distraction.
But it's also a must-win; Vancouver's playoff aspirations grow increasingly foggy with every dropped point as our rivals thump Eastern Conference and higher-ranked teams in a manner that seems calculated to drive a Whitecaps supporter mad.
In trying to map the contact surface responsible for this interaction, it was proposed that the Zn-finger region of GATA2 interacts with the TR DBD in a T3-independent manner, it being sufficient to drive TSHβ down-regulation.
Importantly, upon signaling stimuli, poised enhancers switch to an active chromatin state in a lineage-specific manner and are then able to drive cell-type-specific gene expression patterns.
While it is easy enough to write up a protocol for driving, I wouldn't want to be anywhere on the road near the person who learned to drive in this manner.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com