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The past decade has witnessed the development of a novel class of tools for environmental monitoring: genetically engineered microorganisms 'tailored' to respond in a dose-dependent manner to changes in environmental conditions.
For example, Bayesian adaptive trials designed to adjust in a prespecified manner to changes in clinical practice could motivate people and their health care providers to view clinical trials as more applicable to real-world clinical decisions.
Studies of circular permutants have demonstrated that the folding reaction of S6 from Thermus thermophilus (S6T) is malleable and responds in an ordered manner to changes of the sequence separation between interacting residues: the S6T permutants retain a common nucleation pattern in the form of a two-strand-helix motif that can be recruited from different parts of the structure.
Add the issues surrounding reduced budgets and the ongoing knock on IT workers that they do not respond in a timely manner to changes in business and you have the setting for change.
Secondly, the (reduced) thioredoxin concentration appears to respond in an ultrasensitive manner to changes in the thioredoxin reductase concentration.
33, 34 The times that a certain precept dominates are distributed with a leptokurtic (heavy-tailed) distribution 35 and respond in a well-defined manner to changes in input strength (Levelt's propositions 36).
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When selective populations of neurons are synchronously active they can interact in a Hebbian manner to change the strength of synaptic inputs that are timed at the theta frequency.
We were then able to act in a timely manner to change our recruitment strategies and study protocol.
While there is no easy way to change the manner in which social media are currently used, there may be some reason for hope.
The novel design includes small-scale multi-layered model of buildings where insulation layers can be added to or removed from the building model in a modular and interchangeable manner to allow changes to the thermal performance.
These results suggest that a combination of imaging parameters and assessment of cellular viability in cardiac microtissues can be applied in a high-throughput manner to detect changes in cardiac structure.
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