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But BMI increased with age (age-BMI) in a curvilinear manner, showing a reduction in BMI in elderly.
bFGF down-regulated AR protein in a dose-dependent manner showing a maximal effect at 50 ng ml−1both in the presence or absence of dihydrotestosterone.
In contrast to ALK-negative cells, ALK-positive ALCL and neuroblastoma cells responded to P36 in a dose-dependent manner, showing a decrease of the number of viable cells compared with their untreated control counterpart.
At the protein level, the quantity of VEGF produced by hemSCs decreased in a dose-dependent manner, showing a significant reduction even at a very low concentration (0.02 μmol/L) of propranolol.
In addition, the gene for PacC (pH-responsive transcription factor) was regulated in a carbon source manner, showing a higher expression level in the presence of cellulose (Table 2).
We previously reported that leptin also suppresses 10−10 M ghrelin-induced [Ca2+]i increases in ARC NPY neurons in a concentration-dependent manner showing a maximal effect with 10−12 M leptin [ 19].
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As shown in Figure 5A, Erb-hcAb-RNase inhibited the growth of SKBR3 cells in a dose-dependent manner, showing an antiproliferative effect more potent than that observed for either the parental Erb-hcAb or Herceptin.
Remarkably, when HeLa cells were transfected with pcDNA ER α-flag, E2 regained its ability to upregulate NGB in a dose-dependent manner, showing an effect already at low E2 concentrations (0.1 nM, Figure 1b).
In fact, in her opinion, they just show how easily manipulated some men can be: "To watch Gisele showing clearly that a clever woman can get anything from a man just by behaving in a sexy manner shows a sort of caveman quality that some guys have, and that intelligent women know how to take advantage of it".
Analysis of drug-target networks in a systematic manner shows a rich pattern of interactions among drugs and their targets in which drugs often bind to multiple rather than single molecular targets—a phenomenon known as "polypharmacology" [ 45, 46].
In the present study, we have characterized a mAb that increases the rate of polymerization in a dose-dependent manner, shows a strong preference for polymer over the non-activated monomer, does not affect native state stability against change to an activated intermediate, and does not preferentially act on the barrier between activated monomer and polymer.
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