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In some cases, thioredoxins have been reported to execute their specific functions in a redox-independent manner (reviewed in [2], [3]).
In the developing nervous system, Hairy/E(Spl) homologues can suppress or promote neurogenesis acting in either a Notch-dependent or independent manner (reviewed in [25] and [3]).
Although HIF-1 is generally regulated by pVHL, it has become apparent that more pathways are involved in the regulation of basal HIF-1α levels in an oxygen- and pVHL-independent manner (reviewed in [20], [21]).
FAK can promote cell proliferation and cell survival through the activation of other MAP kinase(s) in a cell-type and experimental context-dependent manner reviewed in [3], [45].
The transition from murine studies to human Phase I Treg clinical trials has been difficult, largely due to difficulties in isolating and expanding Tregs in an Good Manufacturing Practice GMPP) manner (reviewed in Riley et al [38]).
FGF11 was even shown to accumulate in the nucleus in NLS-dependent manner (reviewed in [ 1]).
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Also, it may typically associate with the larger gamete in a quantitative manner (reviewed, e.g. in 6, 25, 44).
The ability to perform such manipulations in essentially any organism has been driven by the use of nucleases that can be targeted to specific sites within the genome in a predictable manner (reviewed by Gaj et al., 2013).
Cardiac fibroblasts in turn can further trigger cardiac inflammation [ 53] in a multimodal manner which is reviewed in detail elsewhere [ 32].
In ER-β ABCDE, the C terminal "F" domain, which is reported to impact receptor dimerization and modulate gene transcription in a ligand-specific manner was deleted reviewed in [ 57].
Assessment of factors contributing to postzygotic interspecific incompatibility that have been identified to the level of operons confirms the traditional view that speciation arises as a by-product of divergence of all manner of genes (reviewed in Orr et al. 2006; Araripe et al. 2010).
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