Recent studies have shown that the N-terminal domain of HSL docks with lipid binding proteins in a phosphorylation-dependent manner, raising the possibility that the size of the N-terminal part of HSL could modulate HSL activation.
Such dogma was recently challenged by reports that dyacylated lipopeptide could engage TLR2 in a TLR6 independent manner raising the possibility that TLR2 might be able to signal as homomers [20].
Although BtpA did not show sequence conservation with the different WxxxE GEF family proteins, the induction of filopodia in a WxxxE-dependent manner raised the question of whether BtpA could also function as a Cdc42 GEF, similar to the EPEC Map protein, that induces filopodia around the infecting bacterium [ 34, 50].
In multivariable (more than two) situations, one time series can be connected to another time series in a direct or an indirect manner, raising the important question of whether there exists a (direct) causal influence between two time series when the influence of other time series are taken into account.
Zaprinast is a selective PDE5/6 inhibitor [17], [18] which in a concentration dependent manner raises intracellular cGMP levels and causes cGMP-dependent photoreceptor degeneration closely resembling the rd1 degeneration (Fig. S2) [19] [19].
Furthermore, there are challenges that stem from teaching increasingly complex, frequently multi-disciplinary, courses in a distributed manner, which raises the demand for appropriately designed intelligent systems that address various learners, in terms of distinctive available and/or desired skills and knowledge.
In his Systême de philosophie, Régis had challenged the claim in the preface to the Recherche that our mind is united to God in a manner that "raises the mind above all things" and is the source of "its life, its light, and its entire felicity" (Malebranche 1958 84, 1 9).
Failure to act in a timely manner typically raises the costs of averting a disaster.
Given that the lentiviral factor, Vpx, can mediate proteasomal degradation of SAMHD1 in a DCAF1/E3 ligase-dependent manner, 37 this raises the question of whether SAMHD1 may also be targeted for proteasomal degradation by as yet unknown physiological pathways.
In this manner, we raised the sensitivity above that obtained by analyzing a single sequence without spuriously counting mutations twice.
