Such dogma was recently challenged by reports that dyacylated lipopeptide could engage TLR2 in a TLR6 independent manner raising the possibility that TLR2 might be able to signal as homomers [20].
Zaprinast is a selective PDE5/6 inhibitor [17], [18] which in a concentration dependent manner raises intracellular cGMP levels and causes cGMP-dependent photoreceptor degeneration closely resembling the rd1 degeneration (Fig. S2) [19] [19].
Recent studies have shown that the N-terminal domain of HSL docks with lipid binding proteins in a phosphorylation-dependent manner, raising the possibility that the size of the N-terminal part of HSL could modulate HSL activation.
Our observation that Slit2 D4 is active on growing RGC axons in a HS-dependent manner raises the possibility that Slit2 D4 might interact with Syndecan to induce a partial cytoskeletal rearrangement, resulting in the bare branch morphology.
In multivariable (more than two) situations, one time series can be connected to another time series in a direct or an indirect manner, raising the important question of whether there exists a (direct) causal influence between two time series when the influence of other time series are taken into account.
The chairperson of a local humanitarian NGO, AY-DER explained their aim in involvement in education provision for Syrian refugees as: Our aim is to supply Syrian brothers/sisters with true knowledge and help them gain good manners, raise their degrees and qualities to become individuals useful for society, and to build bridges between two societies through joint activities with Turkish students.
Physicians openly express emotions like anger, frustration and impatience regularly when interacting with patients, through both physical manners – the use of dismissive body language and facial expressions – and verbal manners – raising one's voice, speaking down to patients and the use of implicit language suggesting contempt.
In a report issued last year, it concluded that enforcement officials involved in the matter "conducted themselves in a manner that raised serious questions about the impartiality and fairness of the insider trading investigation".
As he sits on a low chair, his hands on his haunches, there is something baronial and demanding in the pose, a nearly medieval expectation of large, indecent pleasure; his manner evokes raised flagons, a roasted boar, revels in some upstairs room.
Buyapowa, which works with retailers to turn its fans into shopper advocates in a viral manner, has raised $3 million in Series A funding.
