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Most DNA replication domains, where DNA replication takes place in a nearly synchronous manner, overlap with multiple TADs (Ryba et al. 2010).
In summary, although the genetic regulation of expression levels appears to act in a primarily tissue-dependent manner, overlap is still observed although there appears to be no functional differences in the genes with overlapping eQTL.
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None of the other potential false-positive CISs discovered in this manner overlapped with our list.
To determine whether BOK may have a role in spermatogenesis in a manner overlapping with BAX or BAK, we examined young adult Bok −/− Bak −/− and Bok −/− Bax −/− males (9 14 weeks of age, Figure 4).
Continue lining the coffee filters along the outer edge of the wing in this manner, overlapping them slightly, until you reach the top inside corner.
The manner of overlap for overlapping gene pairs changes very dynamically over evolution; for example, only 95 out of 255 human overlapping gene pairs were reported to be conserved as overlapping pairs in the mouse genome [ 27].
Therefore, we conclude that NDG-4 is functioning in a manner partially overlapping with the IIS pathway.
For example, 20(OH)D3 bound to the G-pocket in a manner that overlapped well with the native ligand 1,25(OH)2D3.
Gantenerumab [ 25] binds Aβ in a manner that overlaps the epitope recognized by 3D6 and offers an interesting comparison.
For example, they should perform this analysis in a genome-wide manner, with overlapping RNA-seq analysis in wild-type and REST -/- cells in the 4 stages (including also mature neurons).
Given that many genome-scale models are built in a similar manner, the small overlap observed for C. beijerinckii suggests that researchers must exercise caution when constructing networks for new organisms using bioinformatics-based annotations alone.
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