Pathologically, UC is characterised by extensive mucosal ulceration and diffuse non-granulomatous inflammation, which usually commences in the rectum and extends proximally in a continuous, confluent, and concentric manner to affect a variable entity of the large bowel.
A single gene could have a dynamic profile across different treatment conditions (a combination of assay, dose and time point) with a role in multiple pathways which interact in complex manners to affect physiological changes of toxicity.
The microneedle geometry, but not the manner of application affected the shape and depth of the conduits.
Possible explanations for this inconsistency include that the mutant Cep290 protein in the mouse and cat models is unstable and degraded, folds in such a manner as to affect the structure of the N-terminal region resulting in alteration of binding properties or results in changes in protein localization.
ER stress also reduces both total and phosphorylated AKT in a severity-dependent manner, without affecting activity of the upstream kinase PDK1.
Our data indicate that cigarette smoking and alcohol use interact in the Chinese population in an additive manner in affecting risk of rectal cancer, thus suggesting that these two exposures may share a common etiologic pathway in rectal carcinogenesis.
In CRNs, secondary users (SUs) are allowed to share the spectrum of primary users (PUs) in an opportunistic manner without affecting the communication performance of the PUs.
Surface properties can be controlled in this manner without affecting the bulk of the material [8, 9].
It is possible that altering the orco expression level may control ORN sensitivity in a quantitative manner by affecting the number of ORs that locate in the dendritic surface.
People often come to my surgery with relationship problems, work-related stress, teenage angst, unhappiness at school: all manner of problems that affect their wellbeing, rather than a designated illness.
Writing for the court, Justice Clarence Thomas said the dispute over the manner of the touch "does not affect our analysis".
