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ICI and spiradoline decreased IOP in a dose-dependent manner in normal rabbits, but only spiradoline produced significant changes in PD.
UVB (290 320 nm wavelengths) exposure before induction of differentiation reduced expression of differentiation-associated proteins, including desmoglein 1 (desmocollinocollin 1 (Dsc1), and keratins 1 and 10 (K1/K10), in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs).
L-ascorbic acid/ tolbutamide produced hypoglycaemic activity in a dose dependant manner in normal and diabetic condition.
They are expressed in a tissue-specific manner in normal organs and the tumours that arise from them.
We found that the intracellular p53 level was also decreased in age-dependent manner in normal human epithelial tissues.
They are expressed in a tissue-specific manner in normal organs as well as in the tumors that derived from them [ 5].
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Furthermore, the new compound exhibited increased cytotoxicity in rat C6 glioma cells in a time- and concentration-dependent manner, whereas in normal human fibroblasts, its IC50 value was > 600 μM versus the IC50 of curcumin found between 100 and 200 μM.
Previous reports have shown that overexpression of L11 in ribosome-perturbed cells, but not in DNA-damaged or oncogene-activated cells, greatly increases L11-MDM2 binding in a p53-dependent manner both in normal and in tumor cells [19], [34].
Using this model, a chemical screen of 5000 candidate small molecules identified two structurally similar compounds that rescued the gridlock phenotype in a dose-dependent manner, resulting in normal flow through the aorta (Peterson et al., 2004).
H2O2 (0.01 1 mM) caused contraction with an augmentation of [Ca2+]i in a concentration-dependent manner in the normal physiological solution containing 2.4 mM of extracellular Ca2+ concentrations.
Dipyridamole increased palmitate oxidation in a concentration-dependent manner in both normal and diabetic myocytes.
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