Sentence examples for manner in cortical from inspiring English sources

The accumulation of APPL was observed in a heterogeneous manner in cortical regions.

Figure 2A shows that quercetin promoted CSPα dimerization in a concentration (20 µM-100 µM) dependent manner in cortical neurons expressing endogenous levels of CSPα.

In clear contrast with physiological conditions, in the pathological brain TIMP-1 expressisn is dramatically induced in a neuronal activity-dependent manner in cortical and hippocampal neurons resistant to excitotoxicity [4].

Importantly, we could detect endogenous complexes of JIP1 and c-Abl in neuronal cells and demonstrate that endogenous JIP1 was phosphorylated on Tyr in a c-Abl-dependent manner in cortical neurons.

Previous studies have indicated that ambient GABA plays a key role in the development of early activity of the brain (Ben-Ari et al., 2007), raising the possibility that GABA-mediated activity controls the expression of Satb1 in an LHX6-dependent manner in cortical interneurons.

Changes in GSK3β activity occur after cerebral ischemia in regional, severity of injury, or model dependent manner: increase in cortical and striatal neurons after global ischemia [ 22]; decreases in the hippocampal CA1 but not CA3 region after global ischemia [ 23].

Moreover, these results suggested that thapsigargin may arrest neuronal survival in a time-dependent manner in cultured cortical neurons.

Deletion of Mcl-1 has been recently linked to elevated mitochondrial dysfunction and activation of either autophagy or apoptosis in a stress- and cell-specific manner in cardiomyocytes, cortical neurons and MEFs.

As reported previously, selective neuronal degeneration occurred in a time-dependent manner in mixed cortical cell culture following GD, whereas purified astrocytes and astrocytes in mixed cultures were resistant for up to 8 h, the longest time-point assessed (Monyer and Choi, 1988; Monyer et al., 1989; Goldberg and Choi, 1993).

In HeLa cells, WDR62 accumulates in the centrosome or nucleus in a cell cycle-dependent manner; siRNA knockdown of WDR62 in cortical progenitors decreased their proliferation, caused defective spindle orientation, and reduced the centrosome integrity, displacement from the spindle poles and late mitotic development [ 31].

Positive effects of a ketogenic diet have also been reported in reducing the cortical contusion volume in an age-dependent manner in an animal model of cortical injury, which is related to the maturation-dependent variability in brain ketone metabolism.